I haven\u2019t written about the pandemic in a while because, well, we have vaccines that work pretty damn well – even against the incredibly contagious delta variant. People just need to get vaccinated. I could do a post every day that just repeats that 500 times I suppose.<\/p>\n\n\n\n
But I was talking to someone and they asked just how bad the delta variant could be for the United States. First off, what is absolutely clear is that:<\/p>\n\n\n\n
Delta is so contagious that, until we get to herd immunity, if you don\u2019t have some sort of immunity or don\u2019t take strong precautions, i.e. N95 masks, social distancing, you <\/em>will <\/em><\/strong>catch it. <\/em><\/p>\n\n\n\n So the most important question is when we will reach herd immunity? That\u2019s actually not an easy question to answer and what answer you get depends on the model you use for herd immunity. And all the models depend on questions we don\u2019t yet have complete answers to, for example: how rare is it that a vaccinated person gets reinfected and if they do get reinfected, how likely will it be that they can transmit it? Similarly, if a person already had a version of Covid and isn\u2019t vaccinated, how likely are they to get reinfected and then transmit delta? And you can also ask: how likely is a child under 12 who catches delta to transmit the virus etc. The point is, the number of groups you can use and how they transmit delta in your model can grow, and then the model becomes very complicated. At that point, large-scale computer simulations are often the best way to get an answer for your model. <\/p>\n\n\n\n But there is some reason to believe that the naive model for calculating herd immunity I discussed here https:\/\/garycornell.com\/2020\/10\/27\/herd-immunity-1\/<\/a> using an R0<\/sub> of roughly 7 (https:\/\/www.thelancet.com\/pdfs\/journals\/lanres\/PIIS2213-2600(21)00328-3.pdf<\/a>) will work pretty well. One can see for example how well it matches up with the Institute for Health Metrics projections which are based on very sophisticated computer simulations. <\/p>\n\n\n\n Using the model I described in my blog and an R0<\/sub> of 7, we need that 85.71% (1-1\/7) of the population to be immune – to not be transmitting the virus to other people – before herd immunity kicks in. So when will 85.71% of the population not be transmitting the virus? <\/p>\n\n\n\n I want to explain how one might get a handle on this number in the rest of this blog. I\u2019m going to make the following simplifying assumption:<\/p>\n\n\n\n This assumes vaccinated people and people who have had Covid are not contributing significantly to the transmission of delta and the transmission from children under 12 also isn\u2019t significant to blocking herd immunity. If these assumptions are false and people in these groups do contribute to transmission significantly, it will make herd immunity happen much later, but based on what I have read so far, current thinking seems to be that this is unlikely.<\/p>\n\n\n\n There are about 329 million people in the United States and about 280 million of them are over the age of 12. <\/p>\n\n\n\n So since 85.71% of the 280 million people over 12 is about 240 million (.8571*240mil=239,988.000),\u00a0we have to find out when 240 million people are not transmitting it to the remaining 40 million people over 12.\u00a0\u00a0<\/p>\n\n\n\n According to the CDC, as I write this, about 185 million people 12 and older have received at least one shot and about 161 million are fully vaccinated. I\u2019m going to assume therefore that we can take 185 million people out of the equation. Let call these people category \u201cA\u201d.\u00a0 Category A lets us remove a lot <\/em>of people from our 240 million goal – if only it were more.\u00a0<\/p>\n\n\n\n Our goal shrinks to:<\/p>\n\n\n\n 240mil – A = 240mill- 185mil = 55 million<\/p>\n\n\n\n So we are down to a goal of 55 million more people being or becoming immune before we get to herd immunity.<\/p>\n\n\n\n This 55 million people goal is made up of two groups in our model. Those who have already had Covid and those who are vulnerable and will get it in the months to come. <\/p>\n\n\n\n To analyze this number, we need to first figure out how many people have gotten Covid and aren\u2019t <\/em>vaccinated. Let\u2019s call the number of people that are 12 and older, aren\u2019t vaccinated, but have been infected <\/em>by Covid, B. This means the number of people who will get sick going forward before we get to our goal of herd immunity is:<\/p>\n\n\n\n 55mill – B<\/p>\n\n\n\n Let\u2019s call this number \u201cV\u201d for vulnerable.<\/p>\n\n\n\n V = 55mill – B<\/p>\n\n\n\n Now we get to the joys of modeling. I have searched for good information on how many people are in group B (have gotten Covid but aren\u2019t vaccinated), but have come up short. There just doesn\u2019t seem to be any good numbers on the size of group B. <\/p>\n\n\n\n But all is not lost: there are good estimates on the total number of people who have been infected by Covid, we just don\u2019t know how to distribute them between groups A (vaccinated) and B (unvaccinated). <\/p>\n\n\n\n The best estimates I have seen are that between two and three times the number of people who have tested positive (roughly 33mil) actually have had COVID. This means it is reasonable to assume between 67 and 100 million people in the United States have had a version of Covid. Let\u2019s be as optimistic as possible and assume that 100 million people over the age of 12 have had some version of Covid. <\/p>\n\n\n\n But we still don\u2019t know how to split these 100 million people between groups A and B is. We have to do this because if they are in group A we have already removed them from the equation, we don\u2019t want to count them twice! How do we proceed?\u00a0 Here\u2019s what we are assuming:<\/p>\n\n\n\n 100mil\/280mill = .357 <\/p>\n\n\n\n So, of the 185 million people in our vaccinated group A, we will assume 35.7% of them have already had Covid:<\/p>\n\n\n\n .357*A = .357*185mil = about 66 million people in group A have had Covid<\/p>\n\n\n\n (Yes, I know that people in group A probably took better precautions, or got vaccinated before they could catch Covid, so their infection rates are lower than group B\u2019s, but you can change this number to take this into account if you want.)<\/p>\n\n\n\n The rest of these 100 million people are exactly the people who have had Covid but aren\u2019t vaccinated i.e. group B. So <\/p>\n\n\n\n B = 100mil – 66 million<\/p>\n\n\n\n This means that, with our assumptions, group B has about 34 million people!<\/p>\n\n\n\n So now let\u2019s calculate V – the people who will get sick from delta before we get to herd immunity with our assumptions. In our model, since V is equal to:<\/p>\n\n\n\n V = 238mil – A – B <\/p>\n\n\n\n or<\/p>\n\n\n\n V = 238mil – 185mil – 34mill <\/p>\n\n\n\n so<\/p>\n\n\n\n V = 55mil – 34mil = 21mil<\/p>\n\n\n\n Our model predicts 21 million more people over 12 will get delta before we get to herd immunity! <\/p>\n\n\n\n Let\u2019s check our simple model against the very sophisticated Institute for Health Metrics (IHME) model which goes until November 2021 (https:\/\/covid19.healthdata.org\/global<\/a>). Their model predicts there will be another 50,000 deaths by November 1st and since the death rate is roughly 1\/10 of the hospitalization rate, their projections imply 500,000 or so hospitalizations (https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2778237<\/a>) by November 1. <\/p>\n\n\n\n Now compare this to the result of our analysis. What we got was 21 million more people who have no immunity will get sick from delta before we get to herd immunity. This implies that there will be roughly 610,000 hospitalizations from delta (best knowledge is that 3% of those infected are hospitalized)\u00a0 and 61,000 more deaths before herd immunity kicks in (using the current knowledge that mortality is 1% of hospitalized cases). This number is consistent with the IHME numbers and probably means our model, simple though it may be, is realistic. Also, if you believe the IHME model and this analysis, we probably won\u2019t get to herd immunity until the beginning of 2022. And, alas if our analysis is right:<\/p>\n\n\n\n hospitals in areas with low vaccination rates i.e. where most of the people in group V live, will not just be overwhelmed by sick patients, they will break completely under the burden.\u00a0<\/em><\/p>\n\n\n\n Feel free to make your own assumptions in this model and change the values for the variables accordingly. But I believe this isn\u2019t a bad model and it gives a good picture, how &^%$<\/em><\/strong> things are going to get in the United States because of the number of people over 12 who are unvaccinated. <\/p>\n","protected":false},"excerpt":{"rendered":" I haven\u2019t written about the pandemic in a while because, well, we have vaccines that work pretty damn well – even against the incredibly contagious delta variant. People just need to get vaccinated. I could do a post every day that just repeats that 500 times I suppose. But I was talking to someone and … Continue reading “When will we get to herd immunity?”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":""},"categories":[6],"tags":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/posts\/675"}],"collection":[{"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/comments?post=675"}],"version-history":[{"count":5,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/posts\/675\/revisions"}],"predecessor-version":[{"id":680,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/posts\/675\/revisions\/680"}],"wp:attachment":[{"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/media?parent=675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/categories?post=675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/garycornell.com\/wp-json\/wp\/v2\/tags?post=675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}